ZP has matured the total antioxidative status sensor (TAS) to a high level including testing in complex animal samples. In the animal studies the sample was placed onto the sensor without dilution. This simple sample preparation is in line with ZP’s philosophy of translating clinical tests into point of care (PoC)/point of need/rapid diagnostic testing (RTD).
The TAS sensors are rapidly deployed on ZP’s SenseItAll (SIA) platform that gives immediate results on a smart phone, whilst also saving the data to the Cloud.
Total Antioxidative Status
Total Antioxidant Status (TAS) is a measure of the overall antioxidant capacity or capability present in a biological sample, such as blood serum or plasma. Antioxidants are substances that can neutralize or scavenge harmful molecules called free radicals, which are produced during normal metabolic processes or as a result of exposure to environmental factors such as pollution, radiation, or toxins.
Free radicals are highly reactive molecules that can cause damage to cells and tissues by oxidizing other molecules, including proteins, lipids, and DNA. This oxidative damage is associated with various diseases and aging processes. Antioxidants work by donating an electron to the free radicals, thereby stabilizing them and preventing or reducing their harmful effects.
Total Antioxidant Status is determined by measuring the cumulative antioxidant activity of all the antioxidants present in a sample. It provides an assessment of the overall ability of the body to counteract oxidative stress. Several laboratory methods and assays are available to measure TAS, including the use of specific chemical reactions or the evaluation of the capacity to inhibit the oxidation of certain substances.
TAS values are often expressed in terms of antioxidant equivalents, such as Trolox equivalents or millimoles of antioxidants per liter (mmol/L). Higher TAS values indicate a higher antioxidant capacity, suggesting a better ability to protect against oxidative damage.
Monitoring TAS can be useful in assessing oxidative stress levels, evaluating the effectiveness of antioxidant therapies or interventions, and understanding the impact of various factors on the body’s antioxidant defense system. However, it’s important to note that TAS is just one aspect of the complex antioxidant system in the body, and it does not provide information about the specific types or concentrations of individual antioxidants present in the sample.