A weekly webinar from ZP ansswering questions from the week.
#electrochemical biosensors
Description:
In this video, I provide an overview of potassium sensors, specifically addressing a recent inquiry regarding their application in blood analysis. The discussion covers key parameters, including the desired measurement range of 2 to 20 millimolar (mM) and an expected accuracy of 80%.
I introduce the potassium sensor and relevant equipment, including the sensor and potentiostat, while emphasizing the importance of proof-of-concept studies. While potassium sensors are available for purchase through Zimmer & Peacock (ZP) for research purposes, formal engagement is recommended for those developing medical diagnostic devices.
Additionally, I clarify that although some clients have successfully used these sensors with blood samples, the available data is derived from buffer solutions, and researchers must independently obtain blood-based data. I discuss signal consistency across different concentrations, demonstrating repeatability within the clinical range. While extrapolation suggests the sensor may perform well in the 2 to 20 mM range, validation through direct experimentation is necessary.
Accuracy is highlighted as a system-dependent factor, influenced by the sensor, sample interaction, electronics, and calibration routines. Consequently, individual laboratory techniques play a crucial role in achieving reliable results.
For those conducting proof-of-concept studies (Technology Readiness Level 3), I discuss the necessary solutions, rinse protocols, and the recommended biosensor circuit for optimal performance. Users opting to utilize the potentiostat are advised to employ open circuit potentiometry, a straightforward measurement technique.
All relevant resources, including data sheets and product links, will be provided for further reference. If you have any questions regarding potassium sensors, please reach out to Zimmer & Peacock for expert guidance.